Home FOR AUTHORS General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.3-11, 2008

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General Physiology and Biophysics Vol.27, p.3-11, 2008

Title: Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet
Author: N. A. Soulimane-Mokhtari, B. Guermouche, M. Saker, S. Merzouk, H. Merzouk, A. Hichami, S. Madani, N. A. Khan, J. Prost
Abstract: The effects of dietary n-3 polyunsaturated fatty acids on lipoprotein concentrations and on lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and lecithin cholesterol acyltransferase (LCAT) activities were studied in streptozotocin-induced diabetic rats during pregnancy and in their macrosomic offspring from birth to adulthood. Pregnant diabetic and control rats were fed Isio-4 diet (vegetable oil) or EPAX diet (concentrated marine omega-3 EPA/DHA oil), the same diets were consumed by pups at weaning. Compared with control rats, diabetic rats showed, during pregnancy, a significant elevation in very low density lipoprotein (VLDL) and low and high density lipoprotein (LDL-HDL1)-triglyceride, cholesterol and apoprotein B100 concentrations and a reduction in apoprotein A-I levels. HTGL activity was high while LPL and LCAT activities were low in these rats. The macrosomic pups of Isio-4-fed diabetic rats showed a significant enhancement in triglyceride and cholesterol levels at birth and during adulthood with a concomitant increase in lipase and LCAT activities. EPAX diet induces a significant diminution of VLDL and LDL-HDL1 in mothers and in their macrosomic pups, accompanied by an increase in cholesterol and apoprotein A-I levels in HDL2–3 fraction. It also restores LPL, HTGL and LCAT activities to normal range. EPAX diet ameliorates considerably lipoprotein disorders in diabetic mothers and in their macrosomic offspring.
Keywords: Diabetes — Lipids — Lipoproteins — Macrosomia — Offspring — Polyunsaturated fatty acids — Pregnancy — Rats
Year: 2008, Volume: 27, Issue: Page From: 3, Page To: 11


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