Home FOR AUTHORS General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.55-58, 2008

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.27, p.55-58, 2008

Title: The effects of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen
Author: M. B. Ponczek, P. Nowak, B. Wachowicz

Abstract: The effect of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen (Fg) in vitro was investigated. We observed that nitration of tyrosine, induced by NO2BF4 (0.01 mmol/l), was increased. No changes in carbonylation by NO2BF4 (0.01 mmol/l) were noticed. Mentioned alterations were associated with amplified coagulation of Fg. Higher concentrations of NO2BF4 (1 and 0.1 mmol/l) triggered growth of nitration and carbonylation of Fg, but led to inhibition of polymerization. Slight nitration may be responsible for increase, whereas sizable nitration and oxidation may lead to inhibition of Fg coagulation.

Keywords: Fibrinogen — Nitrotyrosine — Carbonyl groups — Nitronium ion — Polymerization — Coagulation
Year: 2008, Volume: 27, Issue: Page From: 55, Page To: 58



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