General Physiology and Biophysics Vol.27, p.106-114, 2008

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.27, p.106-114, 2008
Title: Protective effect of stobadine on NCV in streptozotocin-diabetic rats:augmentation by vitamin E
Author: S. Skalska, Z. Kyselova, A. Gajdosikova, C. Karasu, M. Stefek, S. Stolc

Abstract: Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. Elevated reactive oxygen species (ROS) cause cumulative damage to neurons and Schwan cells, however, they also have a deleterious effect on nerve blood flow causing endoneurial hypoxia, which is responsible for early nerve conduction velocity (NCV) deficits and contributes to an increase in resistance to ischaemic conduction failure (RICF). We tested whether antioxidants – stobadine, vitamin E or the combination of these drugs, could prevent the early signs of neural dysfunction in animal model of diabetes in 8–9 weeks old male Wistar rats, made diabetic by streptozotocin (55 mg/kg i.v.) 4 months prior to testing. Neuropathy was evaluated electrophysiologically by measuring motor NCV and RICF of sciatic nerve in vitro. We observed that treatment with the combination of stobadine and vitamin E significantly (p

Keywords: Diabetes — Neuropathy — Oxidative stress — Stobadine — Rats
Year: 2008, Volume: 27, Issue:	Page From: 106, Page To: 114


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