General Physiology and Biophysics Vol.27, p.159-163, 2008

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ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.27, p.159-163, 2008
Title: Multiple treatments with SRIH-14 or octreotide affect adrenal zona glomerulosa in adult male rats
Author: S. Trifunovic, V. Ajdzanovic, B. Sosic-Jurjevic, B. Filipovic, N. Nestorovic, M. Sekulic, V. Milosevic

Abstract: Somatostatin analogues are currently used to treat various disorders such as hypersecretion and different neuroendocrine tumors. In this study we examined the effects on the adrenal cortex of somatostatin (SRIH-14) and octreotide administered subcutaneously twice daily for 5 days to adult male rats. Control rats received saline under the same regime. After sacrifice, the adrenal glands were removed and examined morphometrically using the M42 multipurpose test system. Blood samples were prepared for biochemical tests. Both SRIH-14 and octreotide induced morphofunctional changes in adrenal zona glomerulosa. We found significant decreases (p

Keywords: Adrenal cortex — SRIH-14 — Octreotide
Year: 2008, Volume: 27, Issue:	Page From: 159, Page To: 163


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