Home General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.174-178, 2008

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.27, p.174-178, 2008

Title: Transient outward potassium current in rabbit atrium is depressed after short-time rapid atrial pacing but recovers after a longer pacing period
Author: R. Laszlo, Ch. Eick, M. Schwiebert, B. Schreiner, H. J. Weig, S. Weretka, J. Schreieck

Abstract: In rabbit, after short-time rapid atrial pacing (RAP), atrial ion currents are reduced similarly as in human chronic atrial fibrillation (AF). Using the rabbit model, time-course of transient outward potassium current (Ito) remodeling due to RAP was studied. RAP (600 bpm) was applied via an atrial lead for 0 (control), 24 and 120 h, n = 4 animals/group. Using patch clamp technique in whole-cell mode, current densities and biophysical properties were measured in isolated atrial myocytes. After 24 h of RAP, a reduction of peak Ito (mean ± SEM, test potential +50 mV, +37°C) was observed (60.3 ± 5.4 pA/pF (control, n = 20) vs. 28.0 ± 2.5 pA/pF (24 h, n = 21)). Inactivation of Ito was slower after 24 h, other biophysical properties were unaltered. However, Ito recovered after 120 h: 51.7 ± 4.5 pA/pF (n = 26, p = n.s. vs. control). Inactivation tended to also recover to initial values but was still different to control. Early Ito remodeling due to RAP in rabbits seems to be more complex than previously thought: a time course of Ito remodeling with swayings has to be considered when using the rabbit model of RAP in order to study early remodeling or rather its therapeutic manipulation.

Keywords: Atrial fibrillation — Electrical remodeling — Transient outward potassium current — Rapid atrial pacing — Patch clamp
Year: 2008, Volume: 27, Issue: Page From: 174, Page To: 178

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