General Physiology and Biophysics Vol.27, p.194-202, 2008

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.27, p.194-202, 2008
Title: Modelisation of the contribution of the Na/Ca exchanger to cell membrane potential and intracellular ion concentrations
Author: S. Bahlouli, F. Hamdache, H. Riane

Abstract: Modelisation plays a significant role in the study of ion transfer through the cell membrane and in the comprehension of cellular excitability. We were interested in the selective ion transfers through the KCa, Nav, Cav channels and the Na/Ca exchanger (NCX). The membrane behaves like an electric circuit because of the existence of ion gradients maintained by the cell. The non-linearity of this circuit gives rise to complex oscillations of the membrane potential. By application of the finite difference method (FDM) and the concept of percolation we studied the role of the NCX in the regulation of the intracellular Ca2+ concentration and the oscillations of the membrane potential. The fractal representation of the distribution of active channels allows us to follow the diffusion of intracellular Ca2+ ions. These calculations show that the hyperpolarization and the change in the burst duration of the membrane potential are primarily due to the NCX.

Keywords: Percolation — Finite difference method — Ion channels and concentrations — Current clamp — Voltage clamp
Year: 2008, Volume: 27, Issue:	Page From: 194, Page To: 202


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