Home 
General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.203-210, 2008
General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.203-210, 2008
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.27, p.203-210, 2008 |
||
| Title: Short-term effects of thalidomide analogs on hepatic glycogen and nitric oxide in endotoxin-challenged rats | ||
| Author: E. Fernandez-Martinez, I. Wens-Flores, M. G. Moreno, M. I. Ortiz, P. Muriel, V. Perez-Alvarez | ||
| Abstract: Hepatic glycogen metabolism is altered by nitric oxide (NO) during endotoxic shock. Thalidomide analogs immunomodulate the endotoxin-induced cytokines which regulate the NO release. We analyzed the short-term effects of some thalidomide analogs on the hepatic glycogen store and on the plasma and hepatic NO in an acute model of endotoxic challenge in rat. An endotoxin dose selection was performed. Rats received vehicle, thalidomide or analogs orally and, two hours after last dose, they were injected with endotoxin (5 mg/kg). Animals were sacrificed 2 h after challenge. Liver glycogen was quantified by the anthrone technique. Plasma and hepatic NO was determined by Griess reagent and HPLC. Hepatic interferon-γ, a NO co-inducer, was measured by ELISA. Endotoxin caused inverse dose-dependent effects on plasma NO and on glycogen. Thalidomide analogs showed short-term regulatory effects on glycogen, some of them increased it. Plasma NO was almost unaffected by analogs but hepatic NO was strikingly modulated. Analogs slightly up-regulated the liver interferon-γ and two of them increased it significantly. Thalidomide analogs may be used as a pharmacological tool due to their short-term regulatory effects on glycogen and NO during endotoxic shock. Drugs that increase glycogen may improve liver injury in early sepsis. |
||
| Keywords: Endotoxin — Glycogen — Liver — Nitric oxide — Thalidomide | ||
| Year: 2008, Volume: 27, Issue: | Page From: 203, Page To: 210 | |
|
|
 download file |
|