General Physiology and Biophysics Vol.27, p.222-226, 2008

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.27, p.222-226, 2008
Title: Rats with monosodium glutamate-induced obesity and insulin resistance exhibit low expression of Gαi2 G-protein
Author: M. Baculikova, R. Fiala, D. Jezova, L. Macho, S. Zorad

Abstract: In order to test the potential role of inhibitory G-proteins in mechanisms of insulin resistance in adipose tissue of obese animals we determined the content of Gαi1 and Gαi2 proteins and an extent of protein tyrosine phosphorylation in epididymal fat tissue cell membranes using immunoblot. Monosodium glutamate-induced obese rats displayed adipose tissue hypertrophy, elevated levels of insulin, leptin and slightly elevated serum glucose. We found significantly decreased protein content of Gαi2 in adipose tissue plasma membranes of obese rats. This was in accordance with lower protein tyrosine phosphorylation noticed in adipose tissue cell homogenate of glutamate-treated animals. Our results confirm the role of Gαi2 in development of insulin resistance by crosstalk between the reduced level of inhibitory G-protein and insulin receptor mediated most likely by activation of phosphotyrosine protein dephosphorylation.

Keywords: Obesity — Insulin resistance — Glucose transport — Inhibitory G-protein
Year: 2008, Volume: 27, Issue:	Page From: 222, Page To: 226


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