Home Neoplasma 2005 Neoplasma Vol.52, p.476-482, 2005

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.52, p.476-482, 2005

Title: A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies – three years’ follow-up
Author: A. SYKOROVA, J. HORACEK, P. ZAK, M. KMONICEK, J. BUKAC, J. MALY

Abstract: Forty-four adult autologous transplant patients with hematological malignancies were randomized to receive either prophylactic parenteral nutrition PN (P group), or PN given ad hoc (C group). In each group, they were further randomized to receive standard PN (B group), or PN with 0.5 g glutamine/kg as L-Ala-L-Gln (A group). The overall survival (OS), disease- free survival (DFS) and event-free survival (EFS) in groups C vs. P and A vs. B were compared during follow-up with median 38 months. The final outcome rates in C/P/A/B groups, respectively (OS 65/81/63/85%, EFS 45/53/33/65% and DFS 56/50/35/77%), were not significantly different, apart from A

Keywords: autologous stem cell transplantation, hematological malignancies, parenteral nutrition, glutamine, long-term outcome
Year: 2005, Volume: 52, Issue: Page From: 476, Page To: 482

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