Neoplasma Vol.51, p.30-33, 2004
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Title: Oxidative DNA damage in relation to nutrition
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Author: M., KRAJCOVICOVA-KUDLACKOVA
; M., DUSINSKA
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Abstract: Oxidative DNA damage in humans could arise also from incorrect
nutritional habit and life style. DNA strand breaks with
apurinic/apyrimidinic sites, oxidized purines and oxidized
pyrimidines were assessed in 24 subjectively healthy vegetarians
(plant food, dairy products, eggs) and compared with 24 non-
vegetarians (traditional diet, general population). DNA strand
breaks + oxidized purines are significantly reduced in vegetarians
(p<0.05), DNA strand breaks are nonsignificantly decreased. The
sufficient antioxidative status (overthreshold values of natural
essential antioxidants, which mean a reduced risk of free radical
disease) is crucial in free radical defense. Intake of protective
food commodities (fruit, vegetables, dark grain products, grain
sprouts, oil seeds) is significantly higher in vegetarians.
Alternative nutrition subjects have a significantly increased
plasma levels of vitamin C, vitamin E, ß-carotene with high
incidence of overthreshold values (92% vs. 42% -- vitamin C, 67%
vs. 33% -- vitamin E, 67% vs. 17% -- ß-carotene). There is
recorded a significant inverse linear correlation between values
of DNA strand breaks + oxidized purines and vitamin C or ß-
carotene levels (p<0.01, p<0.05). Vegetarian diet is significantly
more rich source of antioxidants. The results of reduced
endogenous DNA damage and higher antioxidative status in
vegetarians document that a correct vegetarian nutrition might
represent an effective cancer prevention.
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Keywords: DNA damage, vitamin C, ß-carotene, vegetarians, non-vegetarians
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Year: 2004, Volume: 51, Issue: |
Page From: 30, Page To: 33 |
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