Neoplasma Vol.52, p.267-272, 2005
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| Title: Primary lymphoma of the liver – morphological and clinical analysis
of 6 cases. Success of aggressive treatment
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| Author: B., ZIARKIEWICZ-WROBLEWSKA
; B., GORNICKA
; W., SULEIMAN
; T., WROBLEWSKI
; M., MORTON
; G.M., WILCZYNSKI
; H., HELENIAK
; A., SKWAREK
; L., KOPERSKI
; K., DUDEK
; M., KRAWCZYK
; W.W., JEDRZEJCZAK
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Abstract: Histological, clinical and immunohistochemical analysis of 6 cases
of primary liver lymphomas (PLL) are presented.
PLL represents 4.3% of primary malignant liver tumors diagnosed in
our department. The patients were relatively young
people, who despite the presence of a large tumor, were in good
general health status. There were no signs of scirrhosis, and
cancer markers were normal. All lymphomas were CD20, CD79a, BAX
positive, CD3, CD30, EMA, CD10, CD5, CD59,
c-myc, Bcl2, EBV(LMP), CK negative. The proliferation index (Ki67)
was high, ranging from 50–100%. In two cases positive
staining for Bcl6 and in another one for cyclin D1 was obtained.
The major histological type of the tumor was diffuse large B-cell
lymphoma. Positive immunohistochemical results with
BAX and the lack of Bcl2, c-myc and CD59 are associated with
better prognosis. We have not confirmed the value of Bcl6
and CD10 stains as a predictor of poor outcome. Despite clinically
advanced stage at the time of diagnosis, if treated appropriately,
the primary lymphoma of the liver has relatively good prognosis
(five of our patients are alive).
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| Keywords: liver lymphoma, extranodal DLBCL, immunohistochemistry
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| Year: 2005, Volume: 52, Issue: |
Page From: 267, Page To: 272 |
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