Home FOR AUTHORS Neoplasma 2005 Neoplasma Vol.52, p.119-125, 2005

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.52, p.119-125, 2005

Title: Disease status in patients with chronic myeloid leukemia is better characterized by BCR-ABL/BCR transcript ratio than by BCR-ABL transcript level, which may suggest a role of normal BCR gene in the disease pathogenesis
Author: J. MORAVCOVA, J. REGNER, D. MOUCKOVA, K. FISER, V. ZMEKOVA, R. MALACOVA, K. MICHALOVÁ, H. KLAMOVA

Abstract: Monitoring of BCR-ABL transcript level is widely used in chronic myeloid leukemia (CML) to follow up response to therapy. In this study we compare abilities of two quantitative RT-PCR assays to characterize the disease status in CML patients: RT-PCR quantifying the BCR-ABL transcript concentration and RT-PCR determining the BCR-ABL/BCR transcript ratio (R). We demonstrate that in non-responders only R, but not BCR-ABL, unambiguously characterizes the state of disease. Moreover, R values >1 found in all poor responders indicate lower BCR expression compared to BCR-ABL in these patients. Our results demonstrate the importance of BCR-ABL/BCR transcript ratio for the disease status and the disease prognosis characterization and suggest a possible role of the normal BCR gene expression in CML pathogenesis.

Keywords: CML, BCR-ABL, BCR-ABL/BCR, quantitative RT-PCR, disease status, disease prognosis
Year: 2005, Volume: 52, Issue: Page From: 119, Page To: 125



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