Neoplasma Vol.51, p.487-490, 2004
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| Title: Factors influencing outcome of surgery for stage I rectal cancer
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| Author: O., CELEN
; E., YILDIRIM
; U., BERBEROGLU
; |
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Abstract: Stage I rectal cancer (T1N0M0, T2N0M0) carries excellent prognosis
with up to 90% of long term survival rates and complete cure can
be expected with curative surgery. However 10 to 15% of these
patients show local recurrence and mortality seen in five years.
The aim of this study is to analyze the prognostic factors that
influence the overall and disease free survival in patients with
stage I rectal cancer. Eighty-five patients with stage I (T1N0M0,
T2N0M0) rectal cancer that had potentially curative surgery were
entered into the study. The patients were evaluated according to
age, sex, preoperative carcinoembryonic antigen (CEA) level, type
of surgical procedure, tumor distance from anal verge, tumor size,
depth of invasion, histological differentiation, presence of tumor
ulceration, peritumoral vascular invasion, peritumoral lymphatic
invasion and peritumoral perineural invasion. Five year overall
and disease free survival rates for the patients were 88% and 74%,
respectively. Multivariate analysis showed that independent
predictors of recurrence were differentiation and peritumoral
vascular invasion, and independent predictor of overall survival
was only differentiation. Stage I rectal cancer patients with poor
differentiation and peritumoral vascular invasion are at high risk
for recurrence and should be evaluated for adjuvant therapies.
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| Keywords: rectal cancer, stage I, prognosis, recurrence
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| Year: 2004, Volume: 51, Issue: |
Page From: 487, Page To: 490 |
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