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Neoplasma Vol.53, p.87-91, 2006 |
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Title: Stem cell plasticity and carcinogenesis | ||
Author: S., FILIP ; J., MOKRY ; D., ENGLISH ; | ||
Abstract: Presently, there is more and more talk about tumors being a
disease connected with stem cells. Both stem cells and tumor
cells have many similarities, and there is much evidence that
microenvironment, cytokines and signal pathways control tissue
specificities and have a significant role in the process of
carcinogenesis. Recent experimental results show that stem
cells and tumor stem cells apparently play a key role in
carcinogenesis. Tumors grow up, thanks to the activity of just few
stem cells that continuously produce other proliferating
progenitor tumor cells. Generally, tumor elements are thought to be
either undifferentiated, or dedifferentiated cells. Actually, the
truth is that tumors are made of more or less differentiated
cells with variable rate of differentiation. We suppose that under
certain conditions tumor stem cells may participate in regeneration
without giving rise to tumor formation. It is also presumed that
we may reprogram tumor stem cells and progenitor
cells in a certain period of time and so initiate development of
normal tissue. However, till now the real relation between
normal and tumor cells is not clear. Finally, we wish to remind
that plasticity of tumor and normal cells cannot be separated
but should be considered as individual phenomenon expressing
certain condition of an organism in time. This communication
is only a probe and introduction into a discussion aimed at better
understanding of carcinogenesis from the view of processes
at the stem cell level. Stimulation of stem cell activation may
lead to prophylactic approaches for therapy and prevention
in carcinogenesis.
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Keywords: stem cells, tumor stem cells, plasticity, carcinogenesis | ||
Year: 2006, Volume: 53, Issue: | Page From: 87, Page To: 91 | |
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