Neoplasma Vol.52, p.464-468, 2005
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| Title: Expression of the P65 gene in gastric cancer and in tissues with or without Helicobacter pylori infection
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| Author: E., BALCERCZAK
; T., JANKOWSKI
; A., BECHT
; M., BALCERCZAK
; R., JANIUK
; D., JESIONEK-KUPNICKA
; J., SZTOMPKA
; M., MIROWSKI
; |
|
Abstract: A 65-kDa tumor-associated protein (P65) is a potential non-
specific tumor marker expressed by many types of tumor
cells. Our recent studies indicate that P65 gene expression is
connected with poor prognosis for the patients with colorectal
cancer. In the present study P65 gene expression was determined by
means of RT-PCR in the group of 22 gastric cancer and
adjacent normal gastric mucosa. Its presence was correlated with
some parameters of clinical staging. P65 gene expression
was also determined in 102 tissue antral gastric endoscopic biopsy
specimens from the patients suspected of H. pylori infection.
The presence of H. pylori infection was determined by urease test.
We found that in the group of gastric cancers, similarly
to colorectal cancer, P65 gene expression was connected with poor
clinicopathological parameters as T3, lymph nodes
and distant metastases. There was no dependence between P65 gene
expression and H. pylori infection. However, more often
P65 gene expression was detected in the group of infected men than
women. There was also a statistically significant dependence
between age and P65 gene expression in the group of people above
60 years old. It could be then postulated that
P65 gene expression is connected with poor prognosis for the
patients suffering from gastric cancer and that this expression
does not depend on H. pylori infection.
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| Keywords: P65 gene expression, Helicobacter pylori, gastric cancer
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| Year: 2005, Volume: 52, Issue: |
Page From: 464, Page To: 468 |
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