Neoplasma Vol.52, p.1-9, 2005
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| Title: Prognostic and predictive value of cathepsins D and L in operable
breast cancer patients
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| Author: M., JAGODIC
; I., VRHOVEC
; S., BORSTNAR
; T., CUFER
; |
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Abstract: None of the established prognostic factors in breast cancer (BC)
is able to determine the final outcome with certainity. Tumor
biological factors involved in tumor invasion and metastasis, such
as cathepsins and proteins of u-PA system, have been put forward
in the recent literature as strong novel prognostic factors in BC.
We therefore evaluated prognostic and predictive value of
cathepsin-D (CD) and cathepsin-L (CL) in 715 operable BC patients.
CD and CL were determined in tumor extracts using
immunoradiometric and ELISA assays, respectively. During follow-up
(median 37 months), 151 (21%) patients relapsed. In a multivariate
analysis of disease-free survival (DFS), CL (p=0.04), nodal status
(p<0.001) and hormone receptor status (p<0.001) were the only
independent significant prognostic factors. CL thus provided
independent prognostic information on DFS and could also predict a
response to adjuvant chemotherapy (ChT), while CD had no
significant prognostic and predictive impact.
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| Keywords: breast cancer, cathepsin D, cathepsin L, prognosis, treatment
prediction
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| Year: 2005, Volume: 52, Issue: |
Page From: 1, Page To: 9 |
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