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Neoplasma Vol.52, p.441-449, 2005 |
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Title: Anti-apoptotic proteins-targets for chemosensitization of tumor cells and cancer treatment | ||
Author: D., KOSTANOVA-POLIAKOVA ; Ľ., SABOVA ; | ||
Abstract: Apoptosis or programmed cell death is an essential process not
only for the normal development and function of
multi-cellular organisms but it is also an important phenomenon in
tumor cells killing. Numerous studies have indicated that
non surgical cancer therapies eliminate tumor cells by activating
apoptosis. The central regulators of apoptosis are proteins
of the Bcl-2 family. In a wide variety of human tumors, the
increased expression of anti-apoptotic proteins (Bcl-2 and
Bcl-XL) was found. Moreover, it was revealed that high levels of
these proteins block the action of many chemotherapeutic
drugs. Due to this fact the inhibition of anti-apoptotic function
of Bcl-2 proteins could be a strategy for either to restore the
normal apoptotic process in tumor cells or to make them
susceptible for chemo- and radio-therapeutic treatment. Three
alternative
therapeutic strategies for the repression of cytoprotective
activity of anti-apoptotic proteins in tumor cells are reviewed
in this article.
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Keywords: apoptosis, chemoresistance, cancer, Bcl-2 protein family, antisense oligonucleotides, BH3 peptides, BH3 mimetics | ||
Year: 2005, Volume: 52, Issue: | Page From: 441, Page To: 449 | |
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