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Neoplasma Vol.52, p.165-174, 2005 |
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Title: Inoperable oropharyngeal carcinoma treated with concomitant irradiation, mitomycin C and bleomycin – long term results | ||
Author: M., BUDIHNA ; E., SOBA ; L., SMID ; B., ZAKOTNIK ; P., STROJAN ; M., CEMAZAR ; I., FAJDIGA ; M., ZARGI ; A., ZUPEVC ; H., LESNICAR ; | ||
Abstract: Patients with inoperable head and neck tumors were treated
concomitantly with radiochemotherapy with mitomycin C and
bleomycin in our prospective randomized clinical trial (1991–
1993). For the subgroup of patients with oropharyngeal carcinoma
the results with radiochemotherapy were significantly superior to
irradiation alone. Such scheme of treatment was then adopted as
standard method. Here we present the long-term results and dose-
response relationships in patients with inoperable oropharyngeal
carcinoma treated by the same radiochemotherapy scheme till 1997.
Ninety-five patients with stage III and IV inoperable
oropharyngeal squamous cell carcinoma were treated with curative
intent, concomitantly with supravoltage irradiation 2 Gy/day 5
times weekly to 60–73 Gy, bleomycin 5 mg 2 times weekly and. one
application of mitomycin C 15 mg/m2 after 10 Gy. Logistic dose-
response curve was calculated.
Median follow-up was 85 months. The loco-regional control, disease-
free survival and overall survival at 5 years were 55 %, 51 % and
32 % (95 % CI: 44–67 %, 41–62 %, 22–42 %), respectively. The
probability of new primary malignancy at 5 years was 23 %. In
multivariate analysis performance status, biological equivalent
dose, dose of bleomycin, and stage were identified as independent
prognostic factors for loco-regional control, disease-free, and
overall survival. Th g-value of dose response curve was 2.86.
The outcome of the disease was directly proportional to intensity
of irradiation and chemotherapy. It appears that in our
concomitant radiochemotherapy MiC increased radioresponsiveness of
the tumor by its effect on hypoxic fraction.
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Keywords: bleomycin, mitomycin, radiochemotherapy, dose-response, oropharyngeal carcinoma | ||
Year: 2005, Volume: 52, Issue: | Page From: 165, Page To: 174 | |
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