Home Neoplasma 2004 Neoplasma Vol.51, p.293-299, 2004

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.51, p.293-299, 2004

Title: Correlation of vascular endothelial growth factor (VEGF) and CEA with clinicopathological variables in colorectal cancer patients
Author: O., CELEN ; I., KAHRAMAN ; E., YILDIRIM ; U., BERBEROGLU ;

Abstract: The aim of the presented study is to analyze VEGF levels and its correlation with the clinicopathological characteristics of patients with colorectal carcinoma. Thirty-three patients with colorectal adenocarcinoma and 10 healthy controls were evaluated by estimation of VEGF and CEA levels and correlation with clinicopathological features. The serum VEGF and CEA concentrations of colorectal patients were higher than the healthy controls (p<0.05). Patients in advanced stage had high levels of both markers but these differences were not statistically significant. There was a positive correlation between both markers and, tumor size and peritumoral vascular invasion (PVI) but when compared VEGF with CEA, VEGF had a stronger correlation. Diagnostic sensitivity of VEGF for colorectal carcinoma was higher than the sensitivity of CEA and combining both markers the sensitivity to predict colorectal carcinoma was higher than of each marker alone. Our study indicated that VEGF compared to CEA had a higher diagnostic sensitivity for colorectal carcinoma and might provide even additional information about tumor features.

Keywords: vascular endothelial growth factor, VEGF, colorectal cancer
Year: 2004, Volume: 51, Issue: Page From: 293, Page To: 299

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