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Neoplasma Vol.51, p.49-55, 2004 |
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Title: Fine needle aspiration cytology of benign breast disease. Markers of apoptosis and proliferation | ||
Author: J., SWIATECKA ; P., LAUDANSKI ; J., DZIECIOL ; | ||
Abstract: Aim of the study was to compare the fine needle aspiration
cytology findings of benign breast lesions with incidence of
proliferation markers and apoptosis. This study included 37
patients with palpable breast lumps, referred for USG guided FNA.
FNAC were prospectively classified as C2-benign, C4-suspicious of
malignancy, and C5-malignant. The specimens were simultaneously
stained for Ki-67, MPM2, Bcl2 and P53. The diagnoses in group-C2
were following: simple cyst, multiple cysts, simple cyst with
apocrine metaplasia, inflammatory cyst, benign dysplasia (BD) and
benign solid tumors. The final diagnoses, after histopathological
verification, in cases of primary classification as C4 and C5 were
as follow: proliferative fibroadenoma (FAp) and breas cancer,
respectively. Great majority of C2/BD aspirates were negative for
proliferative antigens Ki-67 and PCNA. These antigens were
detected in part of benign solid tumors, as anticipated in
suspicious solid tumor, and in all of cancer aspirates. Bcl-2
immunopositive cells were detected approximately in one quarter of
C2/BD, nearly in half of C2 solid tumors and in one C4/FAp. Most
of diagnosed specimens were P53-negative. Immunocytodetection of
Ki67, MPM2, Bcl2, P53 might be promising, supportive method in the
classification of benign breast lesions. FNAC increases the
reliability of diagnosis when complemented by immunocytochemical
staining. It could be helpful procedure of establishing more
accurately the biology of these lesions and possibly serve as an
essential factor in clinical follow-up. Nevertheless, further
study on larger group of patients comparing cytological and
histopathological diagnosis is required to estimate reliability of
its predictive value.
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Keywords: benign breast disease, fine-needle aspiration, Ki-67, Bcl-2, p53, PCNA | ||
Year: 2004, Volume: 51, Issue: | Page From: 49, Page To: 55 | |
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