Home CONTACT Neoplasma 2005 Neoplasma Vol.52, p.374-380, 2005

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.52, p.374-380, 2005

Title: Second primary tumors (SPT) of head and neck. Distinguishing of “true” SPT from micrometastasis by LOH analysis of selected chromosome regions

Abstract: The reason of treatment failures in head and neck tumors is often connected with the appearance of second primary tumors (SPT). Three mechanisms of SPT development of clonal or non clonal secondary tumors were described: 1° via micrometastases (clonal); 2° from a common carcinogenic field – Second Field Tumors (SFT – partially clonal); 3° via independent events (from different carcinogenic fields – “true” SPT – not clonal). Assessing the clonality of diagnosed tumors carries important clinical implications including chemoprevention, radiotherapy and general patient management.
In this study a set of 12 microsatellite markers was used to find similarities and/or differences in allelic imbalance patterns between 22 pairs of tumors (the first tumor designate as index and SPT). The aim of the study was to identify a potential clonal origin and progression within given pairs of tumors. The results indicate that within the tumors diagnosed by clinical examination as SPT at least two mechanisms mentioned above should be taken into account as 6/23 (26%) were clonally unrelated (“true” SPT) and 3/23 (13%) carried clonal genetic changes (formation by micrometastasis or SFT). In 14/23 (61%) cases the results were insufficient or ambiguous to determine the clonality status. The final results indicate the complexity of carcinogenesis in these tumors and thus stress that clinical diagnosis of second primary tumors should be considered carefully.

Keywords: second primary tumors, head and neck cancer, second field tumors, loss of heterozygosity
Year: 2005, Volume: 52, Issue: Page From: 374, Page To: 380

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