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Neoplasma Vol.51, p.44-48, 2004 |
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Title: Detection of the sentinel node in breast carcinoma using method of a single subcutaneous injection of radiopharmaceutical | ||
Author: H., KRIZOVA ; M., WALD ; P., STRNAD ; J., HERMANSKA ; J., ZIMAK ; P., VLCEK ; | ||
Abstract: The objective of this work is retrospective evaluation of results
of the intraoperative detection of sentinel node in breast
carcinoma after a single subcutaneous injection of
radiopharmaceutical (RF) within a two-day protocol. From May/2001
to June/2002, lymphoscintigraphy of the sentinel node (SN) and its
subsequent radioguided intraoperative detection (RGS) was
performed in 43 women having stage T1--T2, N0 breast carcinoma.
The static scans in the anterior and relevant lateral projections
were performed using a gamma camera at approximately 30-minute
intervals after the subcutaneous administration of 15 MBq 99mTc
Senti-Scint, until the SN was displayed. The localization of the
SN was marked on the overlying skin with a water-resistant
permanent marker in 1--2 projections. RGS was accessed within 18--
24 hours after the injection of the RF and all patients underwent
an axillary dissection. The SN was detected in all patients, and
in all cases was localized in the ipsilateral axilla. In 26
patients (60%), no metastatic process was found either in the SN
or in any other axillary node. However, in one node, deposits of
the carcinoma were detected in surrounding fatty tissue with
propagation along the vessels and nerve. In 16 patients (37%),
metastases in the SN were proved, in 7 cases (16%), a metastatic
process was proved at the same time even in further lymph nodes. A
number of false negative findings (5.8%) is consistent with the
literature data. The method fails in the detection of intramammary
localized SNs.
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Keywords: sentinel node, breast carcinoma, lymphoscintigraphy, Technetium- 99m Senti-Scint, intra-operative gamma probe | ||
Year: 2004, Volume: 51, Issue: | Page From: 44, Page To: 48 | |
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