Neoplasma Vol.50, p.60-65, 2003
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| Title: Bronchial carcinoid tumors: long-term outcome after surgery
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| Author: P., FIALA
; K., PETRASKOVA
; S., CERNOHORSKY
; Z., KINKOR
; E., KREPELA
; P., ZATLOUKAL
; |
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Abstract: The objective of the present study was to evaluate clinical condition and
results of surgical treatment of patients with typical and atypical bronchial
carcinoids. The study was based on retrospective analysis of a total of 96
patients (mean age 47.3 year, age range 21-76, 44 men and women 52), who were
surgically treated for bronchial carcinoid between 1985-2001. We assessed
symptomatology of the disease, type of surgical intervention, tumor histology
and staging, and postoperative 5-year and 10 year survival rates. The main sign
of disease was respiratory inflammation. The carcinoid syndrome was not found in
any patient. Most patients (n=68) were operated for central form of the tumor.
The micromorphological tumor diagnosis was established prior to surgery in 76.5%
patients with the central form of carcinoid. Surgical treatment included
lobectomy (n=49), bronchoplastic procedure (n=14), sleeve lobectomy (n=9),
atypical resection and segmentectomy (n=11), pneumonectomy (n=7) and tumor
enucleation (n=5). Histological analysis revealed typical carcinoid in 77 cases
(80.2%) and atypical carcinoid in 19 (19.8%). Lymph nodes (N1 and/or N2) were
examined by histology in 84 patients and lymph node metastases were found in 13
(19.4%) of 67 patients with typical carcinoid and in 5 cases (29.4%) of 17 with
atypical carcinoid. In the postoperative period on patient died from embolism to
the arteria pulmonalis. Postoperative complications (atelectasis, prolonged air
leak, bronchopleural fistula) were observed in 11.4% of patients. Tumor relapse
occurred only in two patients with typical carcinoid. Postoperative 5-year and
10-year rates amounted to 98.6% and 87.3%, respectively, in typical carcinoid
94.5% and 73.5% in atypical carcinoid. The survival rates of patients with
typical and atypical bronchial carcinoids were not significantly different
(p>0.05). The surgical management is the treatment of choice in bronchial
carcinoids. Results of this study indicate that the 5-year survival in patients
with either histological type of bronchial carcinoid is excellent and the
prognosis of operated patients is very good even in the case of regional lymph
nodes infiltration by the tumors.
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| Keywords: Bronchial cacinoid, lung resection, surival.
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| Year: 2003, Volume: 50, Issue: |
Page From: 60, Page To: 65 |
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