Neoplasma Vol.53, p.43-48, 2006
|
| Title: P53 correlates positively with VEGF in preoperative sera of colorectal cancer patients
|
| Author: W., FAMULSKI
; M., SULKOWSKA
; A., WINCEWICZ
; B., KEDRA
; K., PAWLAK
; B., ZALEWSKI
; S., SULKOWSKI
; M., KODA
; M., BALTAZIAK
; |
|
Abstract: Diversity of P53 impact on tumor angiogenesis is due to the fact
that wild-type P53 decreases expression of vascular endothelial
growth factor (VEGF), but mutant P53 upregulates it.
Therefore, we aimed at uncovering relations between
preoperative serum levels of VEGF and P53 in colorectal cancer
(CRC) patients. Preoperative blood samples of 125 CRC
patients and 16 control healthy volunteers were examined with an
ELISA-kit for serum P53 levels and VEGF. P53 did not
correlate with VEGF in the whole group of CRC patients. However,
P53 associated with VEGF in case of colorectal cancer
patients, whose serum values of VEGF were higher than in controls
(VEGF{H} >5.9333 pg/ml) (r=0.274, p<0.009). We revealed
a positive correlation between P53 and VEGF{H} in subsets of
poorly differentiated (G3) cancers (p<0.02), lymph
node positive (p<0.007), pT3 or pT4 patients (p<0.004) without
analogous relation in moderately differentiated (G2) tumors,
node negative patients or pT1 or pT2 patients. P53 and IGF-I
negatively correlated in all CRC patients (p<0.04) and
VEGF{H} individuals of pT3 or pT4 (p<0.05) without any significant
linkage in tumors of pT1 or pT2. The positive correlation
between serum P53 and VEGF points at mutation of P53 and is a
highly probable sign of poor prognosis in colorectal
cancer. For now it can not be excluded that the binary analysis of
serum P53 and VEGF could help select CRC patients endangered
by rapid growth and lymph node metastases.
|
|
| Keywords: colorectal cancer, P53, VEGF, serum
|
| Year: 2006, Volume: 53, Issue: |
Page From: 43, Page To: 48 |
|
|
|
|
|
 download file |
|
|
|
|
