Home HOME Neoplasma 2004 Neoplasma Vol.51, p.188-192, 2004

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.51, p.188-192, 2004

Title: Potentiation of doxorubicin-induced apoptosis and differentiation by indomethacin in K-562 leukemia cells

Abstract: In this study we have examined the antitumor effect of combined administrations of indomethacin (IND) with doxorubicin (DOX) on growth of K-562 leukemia cells. Although, as single drug treatment, only high concentrations of IND reduced growth (>200 µM) and induced apoptosis (>800 µM) of the K-562 cells, a synergistic effects on DOX-induced cell growth inhibition, apoptosis and differentiation were observed during the co-administration of DOX with 10 µM IND. Cells treated with this combination had elevated GSHt level compare to DOX-treated cells. Modulation of GSHt level of DOX-treated cells with Cd2+ ions or BSO confirmed its important role in processes of DOX-induced differentiation. Results of this study showed that IND has a positive effect on therapeutic efficacy of DOX, and could be a perspective modulator in cancer chemotherapy.

Keywords: indomethacin, doxorubicin, GSH, apoptosis, differentiation, synergism
Year: 2004, Volume: 51, Issue: Page From: 188, Page To: 192

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