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Neoplasma Vol.53, p.343-346, 2006 |
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Title: Evaluation of serum and urine clusterin as a potential tumor marker for urinary bladder cancer | ||
Author: D., STEJSKAL ; R. R., FIALA ; | ||
Abstract: Clusterin is a stress-associated cytoprotective chaperone up-regulated by various apoptotic triggers in many cancers and
neurodegenerative diseases. No valid information about serum or urine clusterin concentration in patiens with bladder cancer
exists.
Aim of our paper was evaluation of the urine and serum clusterin concentrations in individuals with bladder cancer.
Blood and urine samples were used from 43 patients with urothelial tumors of the urinary bladder and from 50 patients with
benign urological diseases. Blood and urine were collected before cystoscopy. Enzyme-linked immunosorbent assays
(ELISA) were performed for clusterin from serum and urine. Serum clusterin was higher in individuals with bladder cancer
(means 185812.5 vs 171946.5 kU/l, p=0.04). Sensitivity for bladder cancer detection was 73% and specificity 55% (AUC
0.63); efficacy was not sufficient. Urine values of clusterin were higher in individuals with bladder cancer (197.2 vs 67.7,
p=0.0007). Sensitivity for bladder cancer detection was 49% and specificity 92% (AUC 0.75, LR+ 6.1, PPV+ 84%); diagnostic
efficacy was sufficient. In conclusion, serum and urine clusterin can differ between bladder cancer patients and the
control group. Urine clusterin could be the possible laboratory marker of bladder cancer. Further research is warranted to
confirm findings in larger studies of various clinical status.
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Keywords: clusterin, urinary bladder cancer, tumor marker | ||
Year: 2006, Volume: 53, Issue: | Page From: 343, Page To: 346 | |
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