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Neoplasma Vol.50, p.262-265, 2003 |
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Title: Effect of tumor stage and nephrectomy on CD62P expression and sP-selectin concentration in renal cancer. | ||
Author: M., MANTUR ; H., KEMONA ; R., KOZLOWSKI ; I., KEMONA-CHETNIK ; | ||
Abstract: The CD62P receptor and its soluble form sP-selectin is a marker of platelet
(PLT) activation, and constitutes a ligand for CD24 antigen of neoplastic cells
and tumor stroma components. The aim of the study was to evaluate the
relationship dynamics of the percentage of CD62P+ platelets, the level of the
receptor expression and the concentration of soluble form of sP-selectin in
renal cancer. Examinations were performed before and after nephrectomy in
patients with renal cancer (group A - 25, T2N0M0; group B - 27, T2N1-2M0) and in
control group (C - 24 subjects). The two groups A and B showed an increased
subpopulation of CD62P+ platelets (p<0.01) and elevated sP-selectin
concentration (p<0.001) before and after nephrectomy. Although following
nephrectomy sP-selectin concentration decreased markedly, it was still higher 3
months after the procedure compared to control group (p<0.05). Following
nephrectomy, however, no statistically significant differences were found in the
% of CD62P+ platelets and the receptor expression. Greater dynamics of changes
before and after nephrectomy in the percentage of CD62P+ platelets (B1:B2
p<0.05) and the receptor expression (B1:B3 p<0.001) was observed in patients
with local lymph node involvement (group B) while sP-selectin concentration was
similar in both groups. Nephrectomy did not normalize intravascular activation
of PLT and TNM had no significant effect on the expression of CD62P and
concentration of sP-selectin.
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Year: 2003, Volume: 50, Issue: | Page From: 262, Page To: 265 | |
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