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Neoplasma Vol.51, p.334-340, 2004 |
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Title: Meta-analyses of clinical trials in patients with non-small cell lung cancer | ||
Author: V., KOVAC ; U., SMRDEL ; | ||
Abstract: Currently lung cancer is the most common worldwide cause of major
cancer incidence and mortality. The treatment outcome is poor and
there are still many questions which remain unanswered such as the
interest of the best treatment schedule. To approach the answer
what is the best treatment for patients with non-small cell lung
cancer (NSCLC) we made a review of the published meta-analyses.
Meta-analysis is a systematic approach to identification and
abstraction of critical information from different randomized,
controlled trials. The review of meta-analyses of clinical trials
we had made showed that
-- in radically operated patients the postoperative radiotherapy
should be detrimental if standard fields are used;
-- postoperative chemotherapy with regimens based on cisplatin has
an absolute benefit of 5% at 5 years survival;
-- we can improve the survival of patients with locally advanced
NSCLC using chemoradiation comparing to radiotherapy alone;
-- chemotherapy with cisplatin can prolong the survival and
improve the quality of life in patients with advanced NSCLC;
-- platinum-based doublets remain the standard regimen in patients
with advanced NSCLC;
-- there is a slight but significant improvement in efficacy of
gemcitabine plus platinum agent when compared with other platinum
based comparators in regard to the survival and time to disease
progression.
In our dealing with NSCLC patients there are still many
controversial opinions, and the meta-analyses are seldom the only
way to find more effective treatment regimen, while the
improvement in lung cancer treatment is a story of small steps.
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Keywords: meta-analysis, non-small-cell lung cancer, chemotherapy, radiotherapy, surgery | ||
Year: 2004, Volume: 51, Issue: | Page From: 334, Page To: 340 | |
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