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Acta Virologica 2005 Acta Virologica Vol.49, p.45-49, 2005
Acta Virologica 2005 Acta Virologica Vol.49, p.45-49, 2005
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Acta Virologica Vol.49, p.45-49, 2005 |
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| Title: HERPES SIMPLEX VIRUS 1 INHIBITS APOPTOSIS THROUGH A CASPASE-3-DEPENDENT PATHWAY IN PRIMARY CULTURES OF CORTICAL NEURONAL CELLS OF FETAL MICE | ||
| Author: J.W. WANG, D.X. WANG, R.J. WANG, W.R. LI, H.Z. TUO, Z.J. FENG | ||
| Abstract: We could induce apoptosis in primary cultures of cortical neurons of fetal mice with ceramide or sorbitol. The induction was accompanied by an increase in caspase-3 (CAS-3) activity and depolarization of the inner mitochondrial membrane of neuronal cells which both could be reversed by Herpes simplex virus 1 (HSV-1) infection. We conclude tha HSV-1 infection inhibited the apoptosis, induced in neuronal cells by sorbitol or ceramide, via a CAS-dependent pathway. |
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| Keywords: apoptosis; caspase-3; Herpes simplex virus 1; cortical neurons | ||
| Year: 2005, Volume: 49, Issue: | Page From: 45, Page To: 49 | |
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