Neoplasma Vol.52, p.143-149, 2005
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| Title: Split-course accelerated hyperfractionation (CHA-CHA) for advanced
head and neck cancers – preliminary results
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| Author: L., MISZCZYK
; G., WOZNIAK
; R., TARNAWSKI
; B., MACIEJEWSKI
; |
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Abstract: The purpose of the study was to evaluate toxicity and
effectiveness of the split course, accelerated hyperfractionation
with a planned gap (CHA-CHA) on a base of the pilot group
treatment results.
The material consisted of 27 patients with advanced (T2 N2c-3, T3-
4 N2), oral cavity, oro- hypopharynx and larynx cancers,
irradiated with a df 1.6 Gy twice a day, with 6-hour gap, up to TD
64 Gy in 28 days, with 8-day gap in a middle. Mean tumor
dimensions were 4.2 and 3.9 cm in X and Y axes, respectively and
mean nodes dimensions 3.9 cm in both axes. The course and
intensity of the mucositis were evaluated in the Dische scale
together with the degree of a tumor and nodes regression. Survival
analysis and dependencies evaluation between physical/biological
factors and treatment results were performed.
The mucositis intensity was high from 2nd to 5th week (the highest
mean – 15 Dische points in 4th week), but on acceptable level.
54.5 % of CR of the tumor and 57.1 % of nodes were noted. Survival
analysis showed 44 % of a 2-year and 35 % of a 4-year OS and 44 %
of a 2-year and 38 % of a 4-year survival excluding deaths from
distant metastases. Correlation between the hemoglobin level and
the nodal regression two months after the radiotherapy (p=0.01),
showed the tumor diameter and TCP (p=0.047), the OS and the nodes
diameter (p=0.004), the PS (p=0.02) and the hemoglobin level
(p=0.04).
CHA-CHA could be a valid method in advanced head and neck cancer
treatment but its efficacy should be confirmed in randomized phase
of trial.
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| Keywords: altered fractionation, accelerated hyperfractionation, split
course, head and neck cancers, radiotherapy
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| Year: 2005, Volume: 52, Issue: |
Page From: 143, Page To: 149 |
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