Home FOR AUTHORS Neoplasma 2005 Neoplasma Vol.52, p.143-149, 2005

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.52, p.143-149, 2005

Title: Split-course accelerated hyperfractionation (CHA-CHA) for advanced head and neck cancers – preliminary results

Abstract: The purpose of the study was to evaluate toxicity and effectiveness of the split course, accelerated hyperfractionation with a planned gap (CHA-CHA) on a base of the pilot group treatment results. The material consisted of 27 patients with advanced (T2 N2c-3, T3- 4 N2), oral cavity, oro- hypopharynx and larynx cancers, irradiated with a df 1.6 Gy twice a day, with 6-hour gap, up to TD 64 Gy in 28 days, with 8-day gap in a middle. Mean tumor dimensions were 4.2 and 3.9 cm in X and Y axes, respectively and mean nodes dimensions 3.9 cm in both axes. The course and intensity of the mucositis were evaluated in the Dische scale together with the degree of a tumor and nodes regression. Survival analysis and dependencies evaluation between physical/biological factors and treatment results were performed. The mucositis intensity was high from 2nd to 5th week (the highest mean – 15 Dische points in 4th week), but on acceptable level. 54.5 % of CR of the tumor and 57.1 % of nodes were noted. Survival analysis showed 44 % of a 2-year and 35 % of a 4-year OS and 44 % of a 2-year and 38 % of a 4-year survival excluding deaths from distant metastases. Correlation between the hemoglobin level and the nodal regression two months after the radiotherapy (p=0.01), showed the tumor diameter and TCP (p=0.047), the OS and the nodes diameter (p=0.004), the PS (p=0.02) and the hemoglobin level (p=0.04). CHA-CHA could be a valid method in advanced head and neck cancer treatment but its efficacy should be confirmed in randomized phase of trial.

Keywords: altered fractionation, accelerated hyperfractionation, split course, head and neck cancers, radiotherapy
Year: 2005, Volume: 52, Issue: Page From: 143, Page To: 149

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