Neoplasma Vol.51, p.164-168, 2004
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| Title: Expression of glucose transporter GLUT-1 and estrogen receptors ER-
? and ER-ß in human breast cancer
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| Author: P., LAUDANSKI
; M., KODA
; L., KOZLOWSKI
; J., SWIATECKA
; M., WOJTUKIEWICZ
; S., SULKOWSKI
; S., WOLCZYNSKI
; |
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Abstract: We attempted to describe a GLUT-1 expression in breast cancer and
characterize correlation between GLUT-1 and ERs ? and ß expression
as well as correlate this with clinicopathologic features.
Sixty-nine patients were involved in the study. GLUT-1, ER-? and
ER-ß immunocytochemistry was performed using the streptavidin-
biotin method.
Thirty-seven (53.6%) out of total 69 were GLUT-1 positive. Of GLUT-
1 positive 45.3% were ER-?-positive, whereas 81.3% of ER-?-
negative were GLUT-1 positive. Statistically significant
correlation was observed between GLUT-1 and ER-? expression status
but neither between GLUT-1 and ER-ß nor with clinicopathologic
features. No statistically significant correlation was found
between expression level (expressed as immunocytoreactive score)
of GLUT-1, ER-? and ER-ß.
Since most of ER-?-negative (81.3%) were GLUT-1 positive and
significant correlation exists between the two receptors it is
reasonable to assume that some functional relation might exists
between the expression of two receptors.
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| Keywords: GLUT-1, ER-?, ER-ß, breast cancer, immunohistochemistry
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| Year: 2004, Volume: 51, Issue: |
Page From: 164, Page To: 168 |
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