Home HOME Neoplasma 2004 Neoplasma Vol.51, p.164-168, 2004

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.51, p.164-168, 2004

Title: Expression of glucose transporter GLUT-1 and estrogen receptors ER- ? and ER-ß in human breast cancer
Author: P., LAUDANSKI ; M., KODA ; L., KOZLOWSKI ; J., SWIATECKA ; M., WOJTUKIEWICZ ; S., SULKOWSKI ; S., WOLCZYNSKI ;

Abstract: We attempted to describe a GLUT-1 expression in breast cancer and characterize correlation between GLUT-1 and ERs ? and ß expression as well as correlate this with clinicopathologic features. Sixty-nine patients were involved in the study. GLUT-1, ER-? and ER-ß immunocytochemistry was performed using the streptavidin- biotin method. Thirty-seven (53.6%) out of total 69 were GLUT-1 positive. Of GLUT- 1 positive 45.3% were ER-?-positive, whereas 81.3% of ER-?- negative were GLUT-1 positive. Statistically significant correlation was observed between GLUT-1 and ER-? expression status but neither between GLUT-1 and ER-ß nor with clinicopathologic features. No statistically significant correlation was found between expression level (expressed as immunocytoreactive score) of GLUT-1, ER-? and ER-ß. Since most of ER-?-negative (81.3%) were GLUT-1 positive and significant correlation exists between the two receptors it is reasonable to assume that some functional relation might exists between the expression of two receptors.

Keywords: GLUT-1, ER-?, ER-ß, breast cancer, immunohistochemistry
Year: 2004, Volume: 51, Issue: Page From: 164, Page To: 168

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