Neoplasma Vol.55, No.1, p.42-46, 2008

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Neoplasma Vol.55, No.1, p.42-46, 2008
Title: Preventive effects of letrozole in the model of premenopausal mammary carcinogenesis
Author: P. KUBATKA, V. SADLONOVA, K. KAJO, G. NOSALOVA, Z. FETISOVOVA

Abstract: Single – agent therapy with aromatase inhibitors has no established role in premenopausal women with breast cancer. In this study, tumor suppressive effects of letrozole in the prevention of N-methyl-N-nitrosourea – induced mammary carcinogenesis in female Sprague-Dawley rats were evaluated. Letrozole was dietary administered in two concentrations – 1 mg/1 kg (LETRO 1), and 10 mg/1 kg (LETRO 10). Letrozole suppressed incidence of mammary gland cancer by 93 % (Pns were not significantly changed. An increase in body weight gain and food intake was found in the groups LETRO 1 and LETRO 10 compared with the control group (P<0.0001). The present study points to high tumor suppressive effects of letrozole in premenopausal model of mammary carcinogenesis in female rats.

Keywords: mammary carcinogenesis, rat, chemoprevention, letrozole, aromatase inhibitors.
Year: 2008, Volume: 55, Issue: 1	Page From: 42, Page To: 46


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