Home HOME Neoplasma 2004 Neoplasma Vol.51, p.71-76, 2004

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.51, p.71-76, 2004

Title: Leukemia-like syndrome in Balb/c mice infected with the lymphotropic gamma herpesvirus MHV-Šumava: an analogy to EBV infection

Abstract: Based on our previous observation that primary infection with the murine gamma herpesvirus (MHV) isolate Šumava (MHV-ŠU) undergoes a lymphoproliferative phase resembling to Epstein-Barr virus (EBV) induced infectious mononucleosis (IM), we evaluated white blood cell (WBC) counts at late stages following MHV-ŠU infection. In consequence of intranasal inoculation with MHV-ŠU a leukemia-like syndrome in Balb/c mice developed. The syndrome in question was accompanied with significant splenomegaly; in the peripheral blood leukocytosis (from 8x104 to 5x105 leukocytes/µl) and a high percentage of atypical lymphocytes (60--80%) was found. Presented results are bringing further evidence for lymphoproliferative effect of MHV and point at analogic course of MHV-ŠU and EBV infections.

Keywords: murine gamma herpesvirus, MHV-Šumava, BALB/c mice, differential white blood cell count, atypical lymphocytes
Year: 2004, Volume: 51, Issue: Page From: 71, Page To: 76

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