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Neoplasma Vol.50, p.26-30, 2003 |
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Title: P53 and C-FOS overexpression in patients with thyroid cancer: an immunohistochemical study | ||
Author: A., KATAKI ; S., SOTORIANAKOS ; N., MEMOS ; M., KARAYIANNIS ; E., MESSARIS ; E., LEANDROS ; A., MANOURAS ; G., ANDROULAKIS ; | ||
Abstract: A sequence of genetic events characterized by deletion and expression of several
oncogenes may lead progressively to tumorgenesis. The expression of certain
oncogenes is believed to be related with thyroid carcinogenesis and tumor
progression. We investigated immunohistochemically p53 tumor suppressor gene and
c-fos oncogene expression in forty patients with thyroid cancer. Thyroid
biopsies from twenty patients with benign thyroid diseases were also examined.
The forty patients with thyroid cancer varied histologically; 24 with papillary
carcinoma (60%), 12 with follicular carcinoma (30%), 3 with anaplastic carcinoma
(7.5%) and one with medullary carcinoma (2.5%). The patients with benign thyroid
diseases consisted of 10 with adenomatous goiter (50%), 7 with goiter (35%) and
three with Hashimoto thyroiditis (15%). Individual p53 and c-fos expression was
more prevalent in thyroid carcinomas compared to benign tumors (p=0.001 and
p=0.04, respectively). A marked increase of p53 and c-fos coexpression was found
(p=0.02) in patients with thyroid cancer and metastasis to the regional lymph
nodes. Furthermore c-fos was overexpressed in only female thyroid cancer
patients. In conclusion, p53 and c-fos are significantly overexpressed in
thyroid cancer patients, indicating their role in the genetic mechanisms leading
to thyroid tumorigenesis. This hypothesis is further supported by the
observation that p53/c-fos coexpression was related with more advanced disease
status.
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Keywords: Thyroid cancer, goiter, thyroiditis, adenoma, p53, c-fos. | ||
Year: 2003, Volume: 50, Issue: | Page From: 26, Page To: 30 | |
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