Neoplasma Vol.52, p.10-17, 2005
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| Title: A new look at the prognostic value of the estrogen, progesterone
and epidermal growth factor receptors in breast cancer tissue
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| Author: E., SKASKO
; Z., PASZKO
; S., MAZUR
; |
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Abstract: The aim of the study was to evaluate the influence of the receptor
status of primary breast cancer and of a number of selected
clinical and morphological patient characteristics. The receptors
were determined by biochemical radiocompetitive methods. Disease
free survival (DFS) and overall survival (OS) were determined by
Cox proportional hazard model. The influence of ER, PR, and EGFR
on patient survival was analyzed in two ways: 1) as a separate
parameter of each receptor and 2) as a common parameter consisting
of 8 variables of concomitant presence or absence of the receptors.
The first set of analyses had shown that EGFR as an independent
parameter had no prognostic value either for DFS or OS because of
a lack of statistical significance. Higher ER concentrations were
positive and lower concentrations were negative prognostic
factors, but only for DFS. PR was always a positive prognostic
factor for DFS and OS and its prognostic value increased with
concentration increase.
In the second analysis it was found that patients with receptor
status ER+PR+EGFR+; ER--PR+EGFR--; ER+PR+EGFR--; and ER--PR--EGFR--
were having better parameters of DFS and OS (relative risks for
DFS or OS were between 0.22--1.16). The patients with receptor
status: ER--PR+EGFR+; ER+PR--EGFR--, ER--PR--EGFR+ and ER+PR--
EGFR+ exhibited a more aggressive disease course (relative risks
for DFS and OS were between 1.46--3.95). Moreover, it was found
that tumor size, nodal status and patient age were independent
prognostic factors for DFS and OS of patients.
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| Keywords: estrogen, epidermal growth factor, progesterone, receptors,
survival
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| Year: 2005, Volume: 52, Issue: |
Page From: 10, Page To: 17 |
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