Neoplasma Vol.50, p.148-151, 2003
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| Title: Inhibition of adhesion breast cancer cells by anticoagulant drugs an cimetidine
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| Author: V., BOBEK
; M., BOUBELIK
; J., KOVARIK
; O., TALTYNOV
; |
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Abstract: Recent studies suggest that anticoagulant drugs and cimetidine therapy in
malignancy may improve cancer survival and inhibit the metastatic process. In
this study we investigated and compared the effects of anticoagulant drugs
(unfractionated heparin, warfarin, acetylsalicylic acid, low-molecular-weight
heparins--nandroparinum, enoxaparinum, dalteparinum and reviparinum), cimetidine
and combination of cimetidine with anticoagulants on adhesion of highly invasive
breast cancer cells lines - BT 549 and MDA-MB-231 (MDA 231)--in vitro. High
antiadhesion effect was observed with cimetidine, warfarin and acetylsalicylic
acid. Low-molecular-weight heparins had a small antiadhesion effect in
independent use. In combination with cimetidine, a potential effect of
cimetidine on the antiadhesion was observed. The antiadhesion effect was
dependent on the type of the cancer cell line. Different effects between cell
lines BT 549 and MDA 231 were observed. The strongest antiadhesion effect was
obtained using the combination of cimetidine with acetylsalicylic acid. In the
majority of applications of the drugs and their combinations, a proportional
antiadhesion effect was dependent on the concentration and time. We suppose that
anticoagulant drugs might have higher antimetastatic effect in combination with
cimetidine. The choice of anticoagulants can decrease the adhesion, decrease
tumor angiogenesis and cause the shortening of blood clotting time. Cimetidine
can decrease the adhesion of cancer cells and increase the activity of NK cells.
Indeed, according to our results, application of cimetidine and anticoagulant
drugs intensifies the antiadhesion effect together with other antimetastatic
effects.
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| Keywords: Breast cancer, metastasis, adhesion, anticoagulation, cimetidine, heparin.
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| Year: 2003, Volume: 50, Issue: |
Page From: 148, Page To: 151 |
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