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Neoplasma Vol.53, p.79-85, 2006 |
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Title: Some biological actions of PEG-conjugated RNase A oligomers | ||
Author: P., POUCKOVA ; J., SKVOR ; G., GOTTE ; F., VOTTARIELLO ; J.T., SLAVIK ; J., MATOUSEK ; D.V., LAURENTS ; M., LIBONATI ; J., SOUCEK ; | ||
Abstract: Previously we have shown that monomeric RNase A has no significant
biological activity, whereas its oligomers (dimer
to tetramer) prepared by lyophilizing from 50% acetic acid
solutions, show remarkable aspermatogenic and antitumor activities.
Furthermore, conjugates prepared by chemical binding of native
RNase A to polyethylene glycol (PEG) have shown a
significant aspermatogenic and antitumor activities. In this work
we show that the chemical conjugation of PEG to the
RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C-
trimer) decreases the aspermatogenic activity of the
oligomers while increasing their inhibitory activity on the growth
of the human UB900518 amelanotic melanoma transplanted
in athymic nude mice. Moreover, the PEG-conjugated RNaseAoligomers
are devoid, like the free oligomers, of any
embryotoxic activity.
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Keywords: RNase A oligomers, polyethylene glycol conjugates, anti-tumor activity, aspermatogenese, melanoma | ||
Year: 2006, Volume: 53, Issue: | Page From: 79, Page To: 85 | |
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