Neoplasma Vol.53, p.79-85, 2006

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.53, p.79-85, 2006
Title: Some biological actions of PEG-conjugated RNase A oligomers
Author: P., POUCKOVA ; J., SKVOR ; G., GOTTE ; F., VOTTARIELLO ; J.T., SLAVIK ; J., MATOUSEK ; D.V., LAURENTS ; M., LIBONATI ; J., SOUCEK ;

Abstract: Previously we have shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetramer) prepared by lyophilizing from 50% acetic acid solutions, show remarkable aspermatogenic and antitumor activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant aspermatogenic and antitumor activities. In this work we show that the chemical conjugation of PEG to the RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C- trimer) decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB900518 amelanotic melanoma transplanted in athymic nude mice. Moreover, the PEG-conjugated RNaseAoligomers are devoid, like the free oligomers, of any embryotoxic activity.

Keywords: RNase A oligomers, polyethylene glycol conjugates, anti-tumor activity, aspermatogenese, melanoma
Year: 2006, Volume: 53, Issue:	Page From: 79, Page To: 85


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