Home Neoplasma 2006 Neoplasma Vol.53, p.434-439, 2006

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6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.53, p.434-439, 2006

Title: Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in freshly isolated rat cells

Abstract: The connection between dietary intake of carboxymethyl chitin- glucan (CM-CG, approximately 200 mg/kg body weight, during 21 days) and the response of freshly isolated rat cells to genotoxic treatment with a combination of photosensitizer Methylene Blue and visible light (MB+VL) was evaluated in presented study. Blood lymphocytes, testicular cells, and hepatocytes were isolated from rats fed by a standard or CM-CG enriched diet and in ex vivo conditions challenged with oxidative agent. Induced DNA damage was assessed using a modified comet assay. When added to the diet, CM-CG itself did not induce any negative effect on the health condition of animals or on level of DNA breaks in rat cells. Moreover, the cells isolated from CM-CG fed animals were more resistant to oxidative stress induced by visible light-excited Methylene Blue. In conclusion, we have demonstrated that carboxymethyl chitin- glucan represents a natural fungal polysaccharide that is able to exert antimutagenic properties upon application in diet.

Keywords: photosensitization, oxidative DNA lesions, carboxymethyl chitin- glucan, diet, comet assay
Year: 2006, Volume: 53, Issue: Page From: 434, Page To: 439

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