Neoplasma Vol.52, p.95-102, 2005
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| Title: The prognostic role of clinical, morphological and molecular
markers in oral squamous cell tumors
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| Author: ZS., NEMETH
; N., VELICH
; S.,
; M., UJPAL
; G.,
; ZS., SUBA
; |
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Abstract: Despite of considerable advances in the diagnostic and therapeutic
possibilities, the prognosis of epithelial tumors in the oral
cavity is still very poor. A knowledge of the prognostic factors
at the begining of treatment is therefore indispensable for
determination of the appropriate therapy for the given patient.
These factors may be linked to the patient (e.g. age, sex, general
condition and immunological parameters) or to the tumor
(localization, TNM stage, histoAbbreviations: AgNOR – argyrophylic
nucleolar organizer regions; AI – apoptotic index; Bcl-2 – protein
which regulates the apoptosis; Cyclin-D1 – protein which regulates
the cell cycle; EGF – epidermal growth factor; EGFR – epidermal
growth factor receptor; ErbB-1 – a gene coding the EGF; FSH –
follicle-stimulating hormon; Ki67 – nuclear antigen; MI – mitotic
index; MMP – matrix metalloproteinase; MVD – capillary-density
(micro vessel density); NK – natural killer; P53 – nuclear
protein; PCNA – proliferating cell nuclear antigen; TGF- –
transforming growth factor-; TE – testosteron; VEGF – vascular
endothelial growth factor.logical features, DNA content
distribution, or immunhistochemical and other parameters). A
survey of the literature reveals that the TNM stage, the grade,
the mode of invasion and the depth of the tumor infiltration are
generally the most important factors influencing the fate of the
patient. The prognosis depends primarily on the
clinicopathological parameters, though even if they are known, it
is not possible to screen out those patients who are at particular
risk of a relapse. During the past 10 years, study of the DNA
content distribution, the proliferation markers and certain
oncogenes has come into the focus of attention; great interest is
also shown in the extracellular matrix components and the
metalloproteinases, which play key roles in the invasion and
metastasis formation.
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| Keywords: oral cancer, prognostic markers, tumor stage, survival
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| Year: 2005, Volume: 52, Issue: |
Page From: 95, Page To: 102 |
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