Neoplasma Vol.53, p.67-72, 2006
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| Title: Risk of malignant tumors in first-degree relatives of patients with differentiated thyroid cancer – a hospital based study
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| Author: D., HANDKIEWCZ-JUNAK
; T., BANASIK
; Z., KOLOSZA
; J., ROSKOSZ
; A., KUKULSKA
; Z., PUCH
; B., JARZAB
; |
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Abstract: In presented study the risk of incidence of familial
differentiated thyroid cancer as well as the risk of other
malignant tumors
in families of DTC patients was evaluated.
999 patients with differentiated thyroid cancer and 825 persons
without any history of malignant disease were evaluated
on the occurrence of malignant neoplasm within their families.
Information about 6614 first degree relatives of DTC index
patients and 4939 first degree relatives of control persons were
recorded. The incidence of cancers at various sites was compared
between first-degree relatives of index patients and control
persons and odds ratio with 95% confidence intervals (CI)
were calculated for thyroid cancer and other cancer sites.
Within 999 families of thyroid cancer index patients 23 families
with more than one case of DTC were found. The risk of
the development of thyroid cancer in the first degree was 6 (95%
CI 1.8–19) times greater in the index group than in the control
group. No increased risk for development of other malignancies was
observed.
Results of our study confirm previous reports of increased risk of
thyroid cancer in first-degree relatives of differentiated
thyroid cancer patients. However, the relatively small number of
first-degree relatives affected with thyroid cancer
(24/6614) does not justify at present any screening in the first-
degree relatives of patients affected with differentiated thyroid
cancer. Simultaneously, no increased risk of other malignant
neoplasm was observed in the differentiated cancer families.
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| Keywords: differentiated thyroid cancer, risk of familiar cancer
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| Year: 2006, Volume: 53, Issue: |
Page From: 67, Page To: 72 |
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