Neoplasma Vol.53, p.372-383, 2006
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| Title: Significance of tenascin-C, fibronectin, laminin, collagen IV,
alpha5beta1 and alpha9beta1 integrins and fibrotic capsule
formation around liver metastases originating from cancers of the
digestive tract
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| Author: M.V., GULUBOVA
; T.I., VLAYKOVA
; |
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Abstract: The formation of a fibrotic capsule around liver metastases may
functionally act as a barrier to local invasion. However,
the prognostic significance of exstracellular matrix (ECM) and of
some integrins’ deposition around liver metastases remains
unclear. An immunohistochemical investigation was carried out on
55 patients with synchronous liver metastases
from colorectal and gastric cancers. Encapsulated metastases were
detected in 60% of the cases. The “non-capsular” cases
showed clear immunostaining for tenascin-C, fibronectin, collagen
IV, laminin, áSMA and integrins. On opposite, most of
the cases with “capsule” were negative for the studied ECM
proteins and the two integrins. The patients with “capsular”
pattern
had significantly longer median survival after the surgery
compared to those with non-encapsulated metastases. The
presence of tenascin, fibronectin, fibronectin receptor and
laminin, as well as the strong immune signal for alphaSMAand
collagen
type IV in the sinusoids attached to the liver metastases was
associated with a worse prognosis. The cells, forming ECM
in the sinusoids attached to metastases in the “non-capsular”
pattern were alphaSMA-positive myofibroblasts. It was shown
ultrastructurally that they were HSCs. The results indicate that
fibrotic capsule formation is associated with longer survival
after surgery. The appearance of tenascin-C and of its receptor at
the periphery of liver metastases could be used as a sign of
invasiveness.
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| Keywords: liver metastasis, colorectal cancer, gastric cancer, fibrotic
capsule, extracellular matrix
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| Year: 2006, Volume: 53, Issue: |
Page From: 372, Page To: 383 |
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