Home CONTACT Neoplasma 2007 Neoplasma Vol.54, p.16-20, 2007

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.16-20, 2007

Title: New [1,2,4]triazolo[4,3-c]quinazoline enhances cisplatin- and temozolomide-induced growth inhibition and apoptosis in HL-60 cells
Author: L. CIPAK, S. LETASIOVA, A. REPICKY, S. JANTOVA

Abstract: The purpose of this study was to investigate the therapeutic potential of a newly synthesized [1,2,4]triazolo[4,3- c]quinazoline (NTCHMTQ) alone and in combination with two anticancer drugs (cisplatin and temozolomide) against HL- 60 leukemia cell line. The IC50 value of NTCHMTQ toward HL-60 cells was 19.7 μM. No apoptosis and cell cycle changes were observed in cells treated with 5 μM NTCHMTQ alone. Combination of non-toxic concentrations of NTCHMTQ (1 – 5 μM) with cisplatin or temozolomide sensitized HL-60 cells to these two drugs and significantly enhanced their efficacies, that is illustrated by combination indexes, sub-G0 cell fraction, apoptotic DNA fragmentation and caspase-3 activity. The results suggest that combined therapy of non-toxic concentrations of NTCHMTQ with chemotherapeutics may provide synergistic regimen for treatment of leukemia. However, further in vitro and in vivo experimental drug-cell and drug-drug studies are warranted.

Keywords: chemotherapy, modulator, quinazoline, apoptosis, cisplatin, temozolomide
Year: 2007, Volume: 54, Issue: Page From: 16, Page To: 20

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