Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.54, p.57-61, 2007 |
||
Title: Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin α and parathymosin in thyroid: novel proliferation markers? | ||
Author: K. P. LETSAS, G. VARTHOLOMATOS, C. TSEPI, A. TSATSOULIS, M. FRANGOU-LAZARIDIS | ||
Abstract: Fine-needle aspiration biopsy-based cytology has become an established and reliable diagnostic preoperative test in the evaluation of thyroid nodules. Despite the high specificity and sensitivity of the method, results might be doubtful in a significant number of cases. Genetic analysis of the aspirates by RT-PCR may contribute, in parallel to the cytology report, to a more precise diagnosis. Prothymosin α and parathymosin are two homologous chromatin remodeling proteins essential
for cell cycle progression and proliferation of either normal or malignant cells. A semi-quantitative RT-PCR assay was developed to determine prothymosin α and parathymosin mRNA expression patterns in thyroid follicular cells obtained from the fine-needle aspiration biopsy specimens of patients diagnosed with simple nodular goitre, follicular adenoma,
papillary and follicular well-differentiated carcinomas. Prothymosin α and parathymosin mRNA levels were found significantly
elevated in well-differentiated carcinomas in relation to adenomas (p<0.05) and goitres (p<0.05), an event possibly linked to the proliferation activity of thyroid follicular cells. Further studies are required to establish prothymosin α and parathymosin
as diagnostic proliferation markers in thyroid cancer, especially in cases of undetermined cellular morphology of follicular origin which reflect the most common cytohistopathological discrepancies. |
||
Keywords: prothymosin α; parathymosin; proliferation marker; cancer; thyroid. | ||
Year: 2007, Volume: 54, Issue: | Page From: 57, Page To: 61 | |
|
download file |
|