Home FOR AUTHORS Neoplasma 2009 Neoplasma Vol.56, No.1, p.40-47, 2009

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Neoplasma Vol.56, No.1, p.40-47, 2009

Title: E-Cadherin truncation and Sialyl Lewis-X overexpression in oral squamous cell carcinoma and oral precancerous conditions
Author: M. H. Shah, R. N. Sainger, S. D. Telang, G. H. Pancholi, S. N. Shukla, P. S. Patel

Abstract:

The present study aimed to determine significance of E-cadherin, a cell adhesion molecule, and sialyl Lewis-X (sLeX), a cell surface antigen, in oral carcinogenesis. Expressions of E-cadherin and sLeX were detected using western blot analysis from oral malignant (n=25), and oral precancerous tissues (OPC, n=20) and their adjacent normal tissues. An altered expression of E-cadherin (E-cad) and sLeX was observed in malignant and precancerous tissues. E-cad western blot revealed presence of two bands, a 120 kDa (native, E-cad120) and a 97 kDa (known as truncated E-cad97). The accumulation of truncated E-cad97 and sLeX in malignant and OPC tissues compared to their adjacent normal tissues was observed. Receiver’s Operating Characteristics (ROC) curve analysis showed good discriminatory efficacy of E-cad97, E-cad97:120 ratio and sLeX between the malignant and adjacent. normal tissues. Further, a positive correlation of E-cad97 and sLeX overexpression with advanced stage of the disease and lymphnode metastasis was observed. The data suggest that E-cadherin truncation and sLeX overexpression are early events which may facilitate the tumor cells to metastasize. Also, overexpression E-cad97 and sLeX in OPC tissues may be useful to predict metastatic potentials of tumors at an early stage of oral carcinogenesis.



Keywords: Oral cancer, oral precancerous conditions, E-cadherin, sialyl Lewis-X, metastasis
Year: 2009, Volume: 56, Issue: 1 Page From: 40, Page To: 47
doi:10.4149/neo_2009_01_40
Price: 19.20 €






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