Home CONTACT Neoplasma 2009 Neoplasma Vol.56, No.1, p.72-75, 2009

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.56, No.1, p.72-75, 2009

Title: Prediction of occult nipple-areola complex involvement in breast cancer patients
Author: K. Gulben, E. Yildirim, U. Berberoglu

Abstract:

The aim of this study was to evaluate predictive factors for the nipple-areola complex (NAC) involvement, and to define a subgroup of patients who may benefit from skin-sparing mastectomy with the NAC preservation in breast cancer patients. Univariate and multivariate analyses were carried out in the retrospective data of 397 eligible patients.

The NAC involvement was histopathologically proved in 58 (14.6%) of the patients. In the multivariate logistic regression analysis showed that tumor location (central vs peripheral; p<0.0001; hazard ratio [HR], 7.5; 95% confidence interval [CI], 3.4-14.6), number of positive axillary lymph nodes (≥10 vs <10; p<0.005; HR, 2.9; CI, 1.3-6.1), and lymphatic vascular invasion (yes vs no; p<0.0001; HR, 3.5; CI, 1.7-7.1) were the most important prognostic factors. Whereas patients with 2 or 3 risk factors were accepted as high-risk group for the NAC involvement, those with no or 1 risk factor was defined as low-risk group. These groups had a 50.0% NAC involvement rate and a 8.1% NAC involvement rate, respectively (p<0.0001). In conclusion, this study showed that patients with 2 or 3 predictive factors had a high risk of the NAC involvement. These risk factors should be taken into consideration in patient selection for skin-sparing mastectomy with the NAC preservation.



Keywords: nipple-areola complex; involvement; breast cancer; mastectomy.
Year: 2009, Volume: 56, Issue: 1 Page From: 72, Page To: 75
doi:10.4149/neo_2009_01_72
Price: 9.60 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.