Home CONTACT Neoplasma 2009 Neoplasma Vol.56, No.1, p.76-83, 2009

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Neoplasma Vol.56, No.1, p.76-83, 2009

Title: The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry
Author: V. Valkova, K. Benesova, A. Vitek, E. Faber, J. Mayer, P. Zak, M. Trneny

Abstract:

We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 30 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduced intensity conditioning (RIC), eleven (23%) pts with myeloablative conditioning (MC). Acute graft-versus-host disease (aGVHD) was recorded in 26 (33%) pts. Chronic GVHD was diagnosed in 19 (36%) of the 53 assessable pts. Transplant-related mortality (TRM) in the first 100 days, 1 year and 3 years for the whole group was 26%, 33% and 33%. Twenty (26%) of the pts relapsed. During the median follow-up of 26 months the overall survival (OS) was 44%, the progression free survival (PFS) was 54% and cumulative incidence of relapse was 45%. Pts with chemoresistant disease had significantly worse results (OS at 3 years 22% vs. 56%, p=0.002). We did not find any correlation between the incidence of GVHD and the frequency of relapse. Similarly, we did not observe any difference in survival between patients following MC vs. RIC. Survival of pts transplanted from related donors did not differ statistically from unrelated donors.



Keywords: Lymphoma, allogeneic, transplantation, GVHD
Year: 2009, Volume: 56, Issue: 1 Page From: 76, Page To: 83
doi:10.4149/neo_2009_01_76
Price: 19.20 €






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