Neoplasma Vol.56, No.2, p.119-123, 2009
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| Title: Overexpression of Wnt-2 in colorectal cancers |
| Author: J. K. Park, J. H. Song, T. C. He, S. W. Nam, J. Y. Lee, W. S. Park |
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Abstract: The binding of the Wnt ligand to its receptor Frizzled, activates the Wnt canonical signaling pathway in carcinogenesis as well as many cellular processes, including cellular proliferation and differentiation. Wnt-2, one of 19 members of the Wnt gene family, is frequently overexpressed in malignant tissues. Here, in order to investigate the role of Wnt-2 in colorectal carcinogenesis, we examined the expression of the Wnt-2 protein in 120 colorectal cancers by immunohistochemistry. Wnt-2 protein was expressed in the cell membrane and cytoplasm and up-regulated in 74 (61.7%) of 120 colorectal cancers. Statistically, overexpression of Wnt-2 protein was not associated with the clinical and pathological parameters studied, including tumor location, tumor size, clinical stage, lymph node metastasis, and 5-year survival (P > 0.05). These results indicate that up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers, as an early event of carcinogenesis.
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| Keywords: Wnt-2 protein, expression, immunohistochemistry, tissue microarray, colon cancer |
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| Year: 2009, Volume: 56, Issue: 2 |
Page From: 119, Page To: 123 |
doi:10.4149/neo_2009_02_119
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